ABSTRACT
Curcumae Longae Rhizoma is a traditional Chinese medicine with the efficacy of activating blood and moving Qi. Curcumin， a polyphenolic substance extracted from the rhizome of plant Curcuma longa， possesses multiple pharmacological activities like anti-tumor， anti-oxidation， anti-bacteria， and anti-inflammation. Laryngeal carcinoma （LC） is a common malignant tumor， whose incidence in recent years has been on the rise， and the 5-year survival rate has continuously decreased. Considering the specific location of larynx， researchers are actively exploring diverse treatment modalities for laryngeal organ preservation. Many studies have shown that curcumin has an inhibitory effect on the development of LC. By virtue of multiple pharmacological effects， curcumin deserves to be thoroughly explored. However， most of the current research is limited to in vitro exploration， and the partial mechanism of curcumin remains unclear， indicating that there is still a long way to go before curcumin becomes a Chinese medicinal preparation for the clinical treatment of LC. This paper reviewed the physicochemical properties of curcumin and the methods for its extraction from plants， the efficacy of curcumin in inducing cell apoptosis and protective autophagy， reversing cell drug resistance， inhibiting cell proliferation， migration， and invasion and tumor angiogenesis， the action mechanism of curcumin in combination with resveratrol， platinum drugs， 3-methyladenine， taxols， and 5-fluorouracil against LC， as well as the bioinformatics analysis concerning curcumin and LC. This paper is expected to provide reference for relevant researchers to clarify the mechanism and important targets of curcumin against LC and promote its clinical application.
ABSTRACT
<p><b>OBJECTIVE</b>To explore the distribution of lecithin-cholesterol acyltransferase gene (LCAT) 608C/T polymorphism in Chinese Han population and the relationship of the polymorphism association with the occurrence of atherosclerotic cerebral infarction.</p><p><b>METHODS</b>The lecithin:cholesterol acyltransferase gene 608C/T polymorphism is identified by polymerase chain reaction (PCR), single-strand conformation polymorphism (SSCP)and restriction fragment length polymorphism (RFLP) in 150 patients with ACI and 122 healthy controls matching age and sex.</p><p><b>RESULTS</b>The distribution of LCAT 608C/T gene polymorphism was in accordance with Hardy-Weinberg equilibrium. The CT genotype frequency (14.0%) and T allele frequency (7.0%) in ACI group were significantly higher than those in control group (P<0.05). The concentration of high density lipoprotein cholesterol (HDL-C) in 608CC subgroups were significantly higher than those in 608CT subgroups both in ACI group and in control group (P<0.05).</p><p><b>CONCLUSION</b>The LCAT 608C/T polymorphism is possibly a predisposing factor in ACI happening of Chinese Han population. T allele frequency is possibly concerned with the metabolism of HDL-C.</p>